UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

THE ISOLATION AND CHARACTERIZATION OF MAGNESIUM WHITLOCKITE CRYSTALS FROM HUMAN ARTICULAR-CARTILAGE

SCOTCHFORD, CA; VICKERS, M; ALI, SY; (1995) THE ISOLATION AND CHARACTERIZATION OF MAGNESIUM WHITLOCKITE CRYSTALS FROM HUMAN ARTICULAR-CARTILAGE. OSTEOARTHR CARTILAGE , 3 (2) 79 - 94.

Full text not available from this repository.

Abstract

A number of basic calcium phosphate crystals have been demonstrated in human articular tissues. The exact relationship between crystal deposition and disease remains obscure, although there is evidence supporting a rapid degenerative arthropathy within a specific set of patients. Limited reports of 'cuboid' calcium phosphate microcrystals in articular cartilage have been made over the last 10 years. In this study the occurrence of such crystals, not apparent by light microscopy, in human articular cartilage has been confirmed by transmission electron microscopy and X-ray microanalysis of tissue prepared by aqueous and anhydrous processing techniques. A crystal isolation technique involving collagenase digestion, centrifugation and sodium hypochlorite treatment was developed enabling crystal characterization by electron and X-ray diffraction. Crystals were identified as magnesium whitlockite; the first report of this mineral in articular cartilage. The presence of this mineral phase in normal and osteoarthritic articular cartilage is discussed with consideration given to physical conditions known to favor whitlockite formation and those extant in articular cartilage.

Type:Article
Title:THE ISOLATION AND CHARACTERIZATION OF MAGNESIUM WHITLOCKITE CRYSTALS FROM HUMAN ARTICULAR-CARTILAGE
Keywords:ARTICULAR CARTILAGE, MAGNESIUM WHITLOCKITE, CRYSTAL ISOLATION, CRYSTAL DEPOSITION DISEASE
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

Archive Staff Only: edit this record