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Free radical generation in rosmarinic acid investigated by electron paramagnetic resonance spectroscopy

Pirker, KF; Kay, CWM; Stolze, K; Tunega, D; Reichenauer, TG; Goodman, BA; (2009) Free radical generation in rosmarinic acid investigated by electron paramagnetic resonance spectroscopy. FREE RADICAL RES , 43 (1) 47 - 57. 10.1080/10715760802585236.

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Abstract

Free radical generation as a result of oxidation reactions of rosmarinic acid (RA), a caffeic acid ester with 3,4-dihydroxyphenyllactate, was investigated by electron paramagnetic resonance (EPR) spectroscopy using a variety of oxidation conditions. Limitations and possibilities of using the various methodologies to obtain information about the reaction chemistry of polyphenols are discussed. Three different spectra were detected dependent on the pH and oxidizing agent. Feasible structures for the observed radicals were tested by density functional theory (DFT) calculations and the results indicate that oxidation reactions can occur at both of the catechol groups.

Type: Article
Title: Free radical generation in rosmarinic acid investigated by electron paramagnetic resonance spectroscopy
DOI: 10.1080/10715760802585236
Keywords: Rosmarinic acid, EPR spectroscopy, auto-oxidation, superoxide anion radical, free radical, SPIN-RESONANCE, CAFFEIC ACID, ANTIOXIDANT ACTIVITY, PHENOLIC-ACIDS, PEROXIDASE, DEGRADATION, SUPEROXIDE, KAEMPFEROL, OXIDATION, SYSTEMS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/71641
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