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Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study

Sodarangani, M; Seaton, C; Scott, JAG; Ogutu, B; Edwards, T; Prins, A; Gatakaa, H; ... Newton, CR; + view all (2008) Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study. LANCET NEUROL , 7 (2) 145 - 150. 10.1016/SI474-4422(07)70331-9.

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Abstract

Background Convulsive status epilepticus (CSE) is the most common neurological emergency in childhood and is often associated with fever. In sub-Saharan Africa, the high incidence of febrile illnesses might influence the incidence and outcome of CSE. We aimed to provide data on the incidence, causes, and outcomes of childhood CSE in this region.Methods Between March, 2006, and June, 2006, we studied all children who had been admitted with CSE to a Kenyan rural district hospital in 2002 and 2003. Confirmed CSE had been observed directly; probable CSE was inferred from convulsions on arrival, requirement for phenobarbital or phenytoin, or coma with a recent history of seizures. We estimated the incidence with linked demographic surveillance, and risk factors for death and neurological sequelae were analysed by multivariable analysis.Findings Of 388 episodes of CSE, 155 (40%) were confirmed CSE and 274 (71%) were caused by an infection. The incidence of confirmed CSE was 35 (95% CI 27-46) per 100000 children per year overall, and was 52 (21-107) and 85 (62-114) per 100 000 per year in children aged 1-11 months and 12-59 months, respectively. The incidence of all CSE was 268 (188-371) and 227 (189-272) per 100000 per year in these age-groups. 59 (15%) children died in hospital, 81 (21%) died during long-term follow-up, and 46 (12%) developed neurological sequelae. Mortality of children with confirmed CSE while in hospital was associated with bacterial meningitis (adjusted relative risk [RR]=2.6; 95% CI 1.4-4.9) and focal onset seizures (adjusted RR=2.4; 1.1-5.4), whereas neurological sequelae were associated with hypoglycaemia (adjusted RR=3.5; 1.8-7.1) and age less than 12 months (adjusted RR=2.5; 1.2-5.1).Interpretation Prevention of infections and appropriate early management of seizures might reduce the incidence and improve the outcome of CSE in children in sub-Saharan Africa.

Type: Article
Title: Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study
DOI: 10.1016/SI474-4422(07)70331-9
Keywords: ACUTE BACTERIAL-MENINGITIS, CLINICAL-FEATURES, TERM MORTALITY, FIRST EPISODE, 1ST EPISODE, ETIOLOGY, CHILDHOOD, EPIDEMIOLOGY, MANAGEMENT, DISTRICT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/71298
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