UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Survival prospects after screen-detection of prostate cancer

Nicholson, PW; Harland, SJ; (2002) Survival prospects after screen-detection of prostate cancer. BJU INT , 90 (7) 686 - 693. 10.1046/j.1464-4096.2002.03005.x.

Full text not available from this repository.

Abstract

Objective To ascertain more realistic survival values for screen-detected prostate cancer than those in current use which are derived from conventionally presenting, usually symptomatic, populations.Materials and methods Survival data for conventionally detected cases were derived from the Surveillance, Epidemiology and End Results database for men diagnosed in the years 1983-1988. The incidence of screen-detected prostate cancer by age and grade was taken from published data.Results For a cohort of men, initially 55 years old, screen-detected cases were estimated to outnumber by 2-3-fold, depending on age, those detected by conventional means. By assuming various survival characteristics for the screen-detected cases the mean lead time was estimated to be 9 years. Because screen-detected cases usually have clinically localized disease they are commonly advised on survival times derived from conventionally detected cases. Applying these survival times over-predicts the number of deaths by factors of at least 3.4, 1.9 and 1.5 at 65, 75 and 85 years old, respectively.Conclusions Screening detects prostate cancer a mean of 9 years before clinical presentation. The prognosis of screen-detected prostate cancer is considerably better than that of conventionally presenting localized disease. The advice given to patients with early prostate cancer should take account of this.

Type: Article
Title: Survival prospects after screen-detection of prostate cancer
DOI: 10.1046/j.1464-4096.2002.03005.x
Keywords: prostate cancer, survival, screening, lead time, ANTIGEN, DIAGNOSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/70218
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item