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The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans

Pannala, AS; Mani, AR; Spencer, JPE; Skinner, V; Bruckdorfer, KR; Moore, KP; Rice-Evans, CA; (2003) The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. FREE RADICAL BIO MED , 34 (5) 576 - 584. 10.1016/S0891-5849(02)01353-9.

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Abstract

Dietary nitrate is metabolized to nitrite by bacterial flora on the posterior surface of the tongue leading to increased salivary nitrite concentrations. In the acidic environment of the stomach, nitrite forms nitrous acid, a potent nitrating/nitrosating agent. The aim of this study was to examine the pharmacokinetics of dietary nitrate in relation to the formation of salivary, plasma, and urinary nitrite and nitrate in healthy subjects. A secondary aim was to determine whether dietary nitrate increases the formation of protein-bound 3-nitrotyrosine in plasma, and if dietary nitrate improves platelet function. The pharmacokinetic profile of urinary nitrate excretion indicates total clearance of consumed nitrate in a 24 h period. While urinary, salivary, and plasma nitrate concentrations increased between 4- and 7-fold, a significant increase in nitrite was only detected in saliva (7-fold). High dietary nitrate consumption does not cause a significant acute change in plasma concentrations of 3-nitrotyrosine or in platelet function. (C) 2003 Elsevier Science Inc.

Type:Article
Title:The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans
DOI:10.1016/S0891-5849(02)01353-9
Keywords:nitrate, nitrite, pharmacokinetics, 3-nitrotyrosine, platelet function, free radicals, S-NITROSO-GLUTATHIONE, NITRIC-OXIDE PATHWAY, BIOLOGICAL-FLUIDS, PLATELET ACTIVATION, TYROSINE NITRATION, NITROTYROSINE, INHIBITION, MECHANISMS, OXIDATION, SPECTROMETRY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics

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