Edwards, JC and Szczepanski, L and Szechinski, J and Filipowicz-Sosnowska, A and Emery, P and Close, DR and Stevens, RM and Shaw, T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med , 350 (25) 2572 - 2581. 10.1056/NEJMoa032534.
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An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, controlled study.
|Title:||Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.|
|Open access status:||An open access version is available from UCL Discovery|
|Keywords:||Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antigens, CD20, Antirheumatic Agents, Arthritis, Rheumatoid, B-Lymphocytes, Bacterial Infections, Cyclophosphamide, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Immunosuppressive Agents, Male, Methotrexate, Middle Aged|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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