Edwards, JC and Szczepanski, L and Szechinski, J and Filipowicz-Sosnowska, A and Emery, P and Close, DR and Stevens, RM and Shaw, T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med , 350 (25) 2572 - 2581. 10.1056/NEJMoa032534.
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Abstract
An open-label study indicated that selective depletion of B cells with the use of rituximab led to sustained clinical improvements for patients with rheumatoid arthritis. To confirm these observations, we conducted a randomized, double-blind, controlled study.
| Type: | Article |
|---|---|
| Title: | Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1056/NEJMoa032534 |
| Language: | English |
| Keywords: | Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antigens, CD20, Antirheumatic Agents, Arthritis, Rheumatoid, B-Lymphocytes, Bacterial Infections, Cyclophosphamide, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Immunosuppressive Agents, Male, Methotrexate, Middle Aged |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) |
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