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Systems-level studies of movement disorders in dystonia and Parkinson's disease

Rothwell, JC; Huang, YZ; (2003) Systems-level studies of movement disorders in dystonia and Parkinson's disease. CURR OPIN NEUROBIOL , 13 (6) 691 - 695. 10.1016/j.conb.2003.10.006.

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Abstract

For many years pathophysiological studies on patients with movement disorders were viewed as inferior to those in animal models because, given the complexity of dealing with the complete interconnected CNS, it was difficult to assign any particular physiological abnormality exclusively to the site of a known lesion. More recently this has come to be seen as an advantage. All the articles reviewed below focus on how healthy parts of the CNS react to damage at a distance, with the result that we are now beginning to have much more insight into how these reactions both compensate and exacerbate the primary deficit.

Type: Article
Title: Systems-level studies of movement disorders in dystonia and Parkinson's disease
DOI: 10.1016/j.conb.2003.10.006
Keywords: TRANSCRANIAL MAGNETIC STIMULATION, FOCAL HAND DYSTONIA, SENSORIMOTOR INTEGRATION, DYT1 DYSTONIA, REPRESENTATION, ABNORMALITIES, PLASTICITY, MODEL, BLEPHAROSPASM, IMPROVEMENT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/69547
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