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Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals?

Mitchell, DGV; Colledge, E; Leonard, A; Blair, RJR; (2002) Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals? NEUROPSYCHOLOGIA , 40 (12) 2013 - 2022.

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Abstract

This study investigates the performance of psychopathic individuals on tasks believed to be sensitive to dorsolateral prefrontal and orbitofrontal cortex (OFC) functioning. Psychopathic and non-psychopathic individuals, as defined by the Hare psychopathy checklist revised (PCL-R) [Hare, The Hare psychopathy checklist revised, Toronto, Ontario: Multi-Health Systems, 1991] completed a gambling task [Cognition 50 (1994) 7] and the intradimensional/extradimensional (ID/ED) shift task [Nature 380 (1996) 69]. On the gambling task, psychopathic participants showed a global tendency to choose disadvantageously. Specifically, they showed an impaired ability to show learning over the course of the task. On the ID/ED task, the performance of psychopathic individuals was not significantly different from incarcerated controls on attentional set-shifting, but significant impairments were found on response reversal. These results are interpreted with reference to an OFC and amygdala dysfunction explanation of psychopathy. Crown Copyright (C) 2002 Published by Elsevier Science Ltd. All rights reserved.

Type: Article
Title: Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals?
Keywords: decision-making, gambling task, risk, response inhibition, intradimensional/extradimensional shifts, response modulation, VENTROMEDIAL PREFRONTAL CORTEX, FACIAL EXPRESSIONS, CRIMINAL PSYCHOPATHS, BASOLATERAL AMYGDALA, NEURAL RESPONSES, STARTLE REFLEX, DISTRESS CUES, EMOTION, DAMAGE, TENDENCIES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/69541
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