Beverley, PC; Linch, DC; Callard, RE; Worman, CP; Cawley, JC; (1982) Cytopenia and T cell proliferation. J Clin Immunol , 2 (3 Suppl) 135S - 141S.
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A group of patients with neutropenia or erythroid aplasia associated with T cell proliferation were evaluated to assess the phenotype(s) and functions of T cells observed in these conditions. These patients have near normal numbers of helper/inducer cells but an excess of cells belonging to the suppressor/cytotoxic subset. The characteristic phenotype of these cells is E+, OKT3+, OKT1+1-, OKT8+, Fc gamma R+, and they frequently bear HLA-DR antigen. These cells respond poorly to T cell mitogens and will suppress the response of normal peripheral blood mononuclear cells to mitogens. They fail to suppress PWM-induced immunoglobulin synthesis. Although the natural killer activity in these patients is sometimes low, this subset of T cells possesses cytotoxic capability demonstrable in assays for antibody-dependent cell-mediated cytotoxicity. The evidence for a direct effect of the T cells on BFUE and CFUGM is poor.
|Title:||Cytopenia and T cell proliferation.|
|Keywords:||Agranulocytosis, Anemia, Aplastic, Animals, Antibodies, Monoclonal, Colony-Forming Units Assay, Humans, Killer Cells, Natural, Lymphocyte Activation, Mice, Mitogens, Neutropenia, Phenotype, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Regulatory|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Haematology|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Infection and Immunity > ICH - Immunobiology Unit
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