Beverley, PC and Linch, DC and Callard, RE and Worman, CP and Cawley, JC (1982) Cytopenia and T cell proliferation. J Clin Immunol , 2 (3 Suppl) 135S - 141S.
Full text not available from this repository.
Abstract
A group of patients with neutropenia or erythroid aplasia associated with T cell proliferation were evaluated to assess the phenotype(s) and functions of T cells observed in these conditions. These patients have near normal numbers of helper/inducer cells but an excess of cells belonging to the suppressor/cytotoxic subset. The characteristic phenotype of these cells is E+, OKT3+, OKT1+1-, OKT8+, Fc gamma R+, and they frequently bear HLA-DR antigen. These cells respond poorly to T cell mitogens and will suppress the response of normal peripheral blood mononuclear cells to mitogens. They fail to suppress PWM-induced immunoglobulin synthesis. Although the natural killer activity in these patients is sometimes low, this subset of T cells possesses cytotoxic capability demonstrable in assays for antibody-dependent cell-mediated cytotoxicity. The evidence for a direct effect of the T cells on BFUE and CFUGM is poor.
| Type: | Article |
|---|---|
| Title: | Cytopenia and T cell proliferation. |
| Location: | UNITED STATES |
| Language: | English |
| Keywords: | Agranulocytosis, Anemia, Aplastic, Animals, Antibodies, Monoclonal, Colony-Forming Units Assay, Humans, Killer Cells, Natural, Lymphocyte Activation, Mice, Mitogens, Neutropenia, Phenotype, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Regulatory |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Haematology UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Infection and Immunity > ICH - Immunobiology Unit |
Archive Staff Only: edit this record