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Switch from alpha v beta 5 to alpha v beta 6 integrin expression protects squamous cell carcinomas from anoikis

Janes, SM; Watt, FM; (2004) Switch from alpha v beta 5 to alpha v beta 6 integrin expression protects squamous cell carcinomas from anoikis. J CELL BIOL , 166 (3) 419 - 431. 10.1083/jcb.200312074. Green open access

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Abstract

Stratified squamous epithelia express the alphavbeta5 integrin, but in squamous cell carcinomas (SCCs) there is down-regulation of alphavbeta5 and up-regulation of alphavbeta6. To investigate the significance of this finding, we transduced an alphav-negative human SCC line with retroviral vectors encoding alphav integrins. alphavbeta5-expressing cells underwent suspension-induced apoptosis (anoikis), whereas alpha-negative cells and cells expressing alphavbeta6 did not. Resistance to anoikis correlated with PKB/Akt activation in suspension, but not with changes in PTEN or p110alpha P13 kinase levels.

Type: Article
Title: Switch from alpha v beta 5 to alpha v beta 6 integrin expression protects squamous cell carcinomas from anoikis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1083/jcb.200312074
Keywords: keratinocyte, apoptosis, differentiation, Akt, extracellular matrix, HUMAN EPIDERMAL-KERATINOCYTES, DETACHMENT-INDUCED APOPTOSIS, AKT/PROTEIN KINASE-B, NF-KAPPA-B, TERMINAL DIFFERENTIATION, INTEGRIN EXPRESSION, SUBCELLULAR-LOCALIZATION, SURVIVAL SIGNALS, BETA-6 INTEGRIN, CANCER CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/6897
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