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Cutting edge: Selection of B lymphocyte subsets is regulated by natural IgM

Baker, N; Ehrenstein, MR; (2002) Cutting edge: Selection of B lymphocyte subsets is regulated by natural IgM. J IMMUNOL , 169 (12) 6686 - 6690.

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Abstract

Natural IgM has a wide range of actions in the immune system. Here we demonstrate that mice lacking serum IgM have an expansion in splenic marginal zone B cells with a proportionately smaller reduction in follicular B cells. The increase in the marginal zone-follicular B. cell ratio (and an expansion in peritoneal B1a cells) is fully reversed by administration of polyclonal IgM, but not by two IgM monoclonals. Mice engineered to have a secreted oligoclonal IgM repertoire with an endogenous membrane IgM also exhibited a similar expansion of marginal zone B cells. We propose that natural IgM, by virtue of its polyreactivity, enhances Ag-driven signaling through the B cell receptor and promotes the formation of follicular B cells. These results demonstrate that natural IgM regulates the selection of B lymphocyte subsets.

Type: Article
Title: Cutting edge: Selection of B lymphocyte subsets is regulated by natural IgM
Keywords: B-1 CELL-DEVELOPMENT, POSITIVE SELECTION, CD22-DEFICIENT MICE, SECRETED IGM, RESPONSES, AUTOANTIBODIES, REPERTOIRE, MATURATION, AUTOIMMUNE, RECEPTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/68199
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