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High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma.

Atra, A; Whelan, JS; Calvagna, V; Shankar, AG; Ashley, S; Shepherd, V; Souhami, RL; (1997) High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma. Bone Marrow Transplant , 20 (10) pp. 843-846. 10.1038/sj.bmt.1700992.

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Abstract

Eighteen patients with poor risk Ewing's sarcoma (including 11 patients with metastatic disease at presentation) received consolidation therapy of busulphan and melphalan with autologous stem cell rescue. There were nine females. The median age at diagnosis was 14.2 years (range 2.75-30 years). There was one early death due to cytomegalovirus pneumonitis. One patient developed a single generalised convulsion during busulphan therapy. Severe renal toxicity was not encountered. One patient developed veno-occlusive disease of the liver (VOD) which eventually resolved. With a median follow up of 2 years, 13 patients survive including six with initial metastatic disease. We conclude that high-dose busulphan/melphalan is well-tolerated and should be evaluated for efficacy in a larger series of patients with high risk Ewing's sarcoma.

Type: Article
Title: High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma.
Location: England
DOI: 10.1038/sj.bmt.1700992
Keywords: Adolescent, Adult, Anticonvulsants, Antineoplastic Combined Chemotherapy Protocols, Bone Neoplasms, Busulfan, Child, Child, Preschool, Clonazepam, Combined Modality Therapy, Contraindications, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation, Hepatic Veno-Occlusive Disease, Humans, Male, Melphalan, Neoplasm Metastasis, Phenytoin, Remission Induction, Sarcoma, Ewing, Seizures, Survival Analysis, Transplantation Conditioning, Treatment Outcome
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Development Bio and Cancer Prog
URI: http://discovery.ucl.ac.uk/id/eprint/67482
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