Jalan, R; Davies, NA; Damink, SWMO; (2002) Hypothermia for the management of intracranial hypertension in acute liver failure. METABOLIC BRAIN DISEASE , 17 (4) 437 - 444.
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Increased intracranial pressure in patients with acute liver failure (ALF) remains a major immediate cause of mortality. Several studies in animal models of ALF set the stage for the clinical application of moderate hypothermia in man. Studies in patients with ALF and increased intracranial hypertension have shown that temperatures as low as 32degreesC are safe and effectively reduce increased intracranial pressure unresponsive to other medical therapies, and can be used as a successful bridge to liver transplantation. Data from studies in patients undergoing liver transplantation for ALF suggest that increases in intracranial pressure can be prevented during the dissection and reperfusion phases of the operation if the patients are maintained hypothermic during surgery. The present review focuses upon the clinical aspects of using hypothermia as a treatment of increased intracranial pressure in patients with ALF.
|Title:||Hypothermia for the management of intracranial hypertension in acute liver failure|
|Keywords:||acute liver failure, intracranial pressure, hypothermia, liver transplantation, FULMINANT HEPATIC-FAILURE, CEREBRAL-BLOOD-FLOW, INDUCED BRAIN EDEMA, MODERATE HYPOTHERMIA, MILD HYPOTHERMIA, TOTAL HEPATECTOMY, PORTACAVAL ANASTOMOSIS, BODY-TEMPERATURE, CONTROLLED TRIAL, ENCEPHALOPATHY|
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