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The evolution of protein functions and networks: a family-centric approach

Dessailly, BH; Reid, AJ; Yeats, C; Lees, JG; Cuff, A; Orengo, CA; (2009) The evolution of protein functions and networks: a family-centric approach. BIOCHEMICAL SOCIETY TRANSACTIONS , 37 745 - 750. 10.1042/BST0370745.

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Abstract

The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure-function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein-protein complexes.

Type: Article
Title: The evolution of protein functions and networks: a family-centric approach
Location: Cambridge, ENGLAND
DOI: 10.1042/BST0370745
Keywords: database analysis, domain superfamily, protein function, protein network, structure-function relationship, DATABASE, SUPERFAMILIES, ANNOTATION, SEQUENCE, GENOMES, SYNTHETASE, DIVERGENCE, DIVERSITY, RESOURCE, DOMAINS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/66808
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