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A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population

Wallace, E; Hinds, A; Campbell, H; Mackay, J; Cetnarskyj, R; Porteous, ME; (2004) A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population. British Journal of Cancer , 91 (8) pp. 1575-1579.

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Abstract

A cross-sectional survey of all patients aged 30-65 in four general practices within one Local Health Care Co-operative in Fife, Scotland was undertaken to measure the prevalence of family history of colorectal, breast and ovarian cancer. A total of 7619 patients aged 30-65 responded to a postal questionnaire (response rate 59%). In all, 17% of respondents (1324, 95% Cl 16-18%) reported a relative affected by colorectal, breast or ovarian cancer. Of those, 6% (78, 95% CI 5-7%) met the Scottish guidelines for referral for genetics counselling. In all, 2% (24, 95% CI 1-3%) of all individuals with an affected relative had received genetic counselling and risk assessment. Of these, 25% (6, 95% CI 8-42%) met the moderate- or high-risk criteria for developing a cancer. In conclusion, the number of patients who are at a significantly increased risk of cancer on the basis of a family history is small (approximately 10 per General Practitioner (GP) list). It is therefore unrealistic to expect GPs to develop expertise in genetic risk estimation. A simple family history chart or pedigree is one way that a GP can, within the constraints of a GP consultation, determine which patients should be reassured and which referred to the local cancer genetic clinic

Type: Article
Title: A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population
Additional information: DA - 20041013IS - 0007-0920LA - engPT - Journal ArticleSB - IM
Keywords: 10, A, Adult, Aged, ALL, AND, ARTICLE, assessment, BREAST, Breast Neoplasms, CANCER, CARE, Colorectal Neoplasms, Comparative Study, Counselling, Cross-Sectional Studies, Epidemiology, families, FAMILY, Family Health, Family Practice, FEMALE, FOR, Genetic, Genetic Predisposition to Disease, genetics, Genetics, Population, GUIDELINES, HAD, HEALTH, HEALTH-CARE, Histories, history, HUMANS, IM, INDIVIDUALS, IS, JOURNAL, LA, Male, Middle Aged, NUMBER, OF, Ovarian Neoplasms, PATIENT, patients, Pedigree, Population, PREVALENCE, QUESTIONNAIRE, Questionnaires, Research Support, Non-U.S.Gov't, RISK, Risk Assessment, Risk Factors, Scotland, small, survey, THE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/66772
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