UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors

Morris, PJ; Lakin, ND; Dawson, SJ; Ryabinin, AE; Kilimann, MW; Wilson, MC; Latchman, DS; (1996) Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. MOL BRAIN RES , 43 (1-2) 279 - 285.

Full text not available from this repository.

Abstract

The three members of the Brn-3 subfamily of POU transcription factors have distinct effects on target gene expression. We show that the promoter of the gene encoding the presynaptic nerve terminal protein SNAP-25 resembles previously characterised target genes in being activated by Brn-3a and Brn-3c, but being repressed by Brn-3b. Unlike other target genes, however, the SNAP-25 promoter can be activated by either the N- or C-terminal activation domains of Brn-3a. In contrast to the SNAP-25 gene, the gene encoding the synaptic vesicle protein synapsin I is activated by all the Brn-3 factors, the first gene for which this activation pattern has been reported. Interestingly, however, similar activation by all three Brn-3 factors can be observed if the SNAP-25 promoter is truncated by removal of sequences from -2200 to -288 relative to the transcriptional start site. Moreover, a region of the SNAP-25 promoter from -288 to -126 can render a heterologous promoter responsive to activation by all three Brn-3 factors. Differences in promoter structure may thus result in differences in the response to different Brn-3 factors, thus allowing these factors to produce diverse activation patterns of neuronally expressed genes, such as those encoding different synaptic proteins.

Type: Article
Title: Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors
Keywords: transcriptional control, POU family transcription factor, Brn-3, synapsin, SNAP-25, NEURONAL CELLS, FAMILY, DOMAIN, EXPRESSION, PROMOTER, SERUM, REDISTRIBUTION, HOMEODOMAIN, OPPOSITE, ELEMENTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
URI: http://discovery.ucl.ac.uk/id/eprint/65948
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item