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Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses

Sjostrom, PJ; Turrigiano, GG; Nelson, SB; (2007) Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses. NEUROPHARMACOLOGY , 52 (1) 176 - 184. 10.1016/j.neuropharm.2006.07.021.

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Abstract

Long-term potentiation and depression (LTP and LTD) are cellular plasticity phenomena expressed at a variety of central synapses, and are thought to contribute to learning and developmental changes in circuitry. Recurrent neocortical layer-5 synapses are thought to express a presynaptic form of LTP that influences the short-term plasticity of the synapse. Here we show that changes in synaptic strength elicited by pairing high frequency pre- and postsynaptic firing at this synapse result from a mixture of presynaptic and postsynaptic forms of plasticity, as assessed by the analysis of changes in coefficient of variation, short-term plasticity, and NMDA:AMPA current ratios. Pharmacological dissection of this plasticity revealed that block of presynaptic LTD with an endocannabinoid inhibitor enhanced LTP, while the apparently presynaptic component of UP could be prevented by induction in the presence of blockers of nitric oxide. These data suggest that correlated high-frequency firing at layer-5 synapses simultaneously induces a mixture of presynaptic LTD, presynaptic LTP, and postsynaptic LTP. (c) 2006 Elsevier Ltd. All rights reserved.

Type: Article
Title: Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses
DOI: 10.1016/j.neuropharm.2006.07.021
Keywords: long-term potentiation, long-term depression, nitric oxide, endocannabinoid, neocortical layer 5, AMPA RECEPTOR TRAFFICKING, GUIDED LASER STIMULATION, NITRIC-OXIDE SYNTHASE, SYNAPTIC PLASTICITY, PYRAMIDAL NEURONS, SILENT SYNAPSES, RELEASE PROBABILITY, PRESYNAPTIC RELEASE, NERVOUS-SYSTEM, POTENTIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/65854
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