UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Correlation-based multivariate analysis of genetic influence on brain volume

Hardoon, DR; Ettinger, U; Mourao-Miranda, J; Antonova, E; Collier, D; Kumari, V; Williams, SCR; (2009) Correlation-based multivariate analysis of genetic influence on brain volume. NEUROSCI LETT , 450 (3) 281 - 286. 10.1016/j.neulet.2008.11.035.

Full text not available from this repository.


Considerable research effort has focused on achieving a better understanding of the genetic correlates of individual differences in volumetric and morphological brain measures. The importance of these efforts is underlined by evidence Suggesting that brain changes in a number of neuropsychiatric disorders are at least partly genetic in origin. The Currently used methods to study these relationships are mostly based oil single-genotype univariate analysis techniques. These methods are limited as multiple genes are likely to interact with each other in their influences on brain Structure and function. In this paper we present a feasibility study where we show that by using kernel correlation analysis, with a new genotypes representation, it is possible to analyse the relative associations of several genetic polymorphisms with brain structure. The implementation of the method is demonstrated on genetic and structural magnetic resonance imaging (MRI) data acquired from a group) Of 16 healthy subjects by showing the multivariate genetic influence on grey and white matter. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Correlation-based multivariate analysis of genetic influence on brain volume
DOI: 10.1016/j.neulet.2008.11.035
Keywords: Canonical correlation analysis, Kernel methods, Multivariate genetic analysis, Multivariate sMRI analysis, SCHIZOPHRENIA, METAANALYSIS, POPULATION, TWINS
UCL classification: UCL > Office of the President and Provost
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/65639
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item