Mercuri, E and Poulton, J and Buck, J and Broadbent, V and Bamford, M and Jungbluth, H and Manzur, AY and Muntoni, F (1999) Vincristine treatment revealing asymptomatic hereditary motor sensory neuropathy type 1A. ARCH DIS CHILD , 81 (5) 442 - 443.
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A 5 year old boy developed severe weakness after receiving vincristine for treatment of acute lymphoblastic leukaemia. Although weakness improved after the discontinuation of vincristine, other symptoms suggestive of a neuropathy persisted. Neurophysiological and genetic analysis at age 8 years indicated that vincristine had induced symptoms of a hereditary sensory motor neuropathy type 1A, which had previously been asymptomatic; his genetically affected mother was also asymptomatic.
|Title:||Vincristine treatment revealing asymptomatic hereditary motor sensory neuropathy type 1A|
|Keywords:||vincristine, hereditary sensory motor neuropathy type 1A, neuropathy, acute lymphoblastic leukaemia, MARIE-TOOTH DISEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Neurosciences and Mental Health > ICH - Dubowitz Neuromuscular Centre|
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