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A New View of Innate Immunity for the 21st Century

Wright, J; Bryant, CE; (2009) A New View of Innate Immunity for the 21st Century. In: Henderson, B and Curtis, M and Seymour, R, (eds.) Periodontal Medicine and Systems Biology. (247 - 262). Blackwell Pub

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Abstract

Our understanding of innate immunity has progressed at an extremely rapid pace over the past decade, in particular focussing on the mechanisms by which microbes are recognised and the signalling events which lead to responses against them. In both areas, research into Toll-like receptors (TLRs) has led the way, and our understanding of microbial ligand recognition by this family of 10 receptors, and the complex interlinking signalling pathways that operate downstream of them has progressed immensely. Comprehension of other families of pattern recognition receptors lags some way behind, although progress in determining their ligand specificity and signal transduction has been made. Unsurprisingly, for a relatively new field, much of the research has not focussed on dental pathogens or tissues, instead using better characterised systems to elucidate the basic mechanisms of these molecules. However, some attention is now beginning to focus on periodontal tissues and associated pathogens, and a role for these systems is becoming evident.

Type:Book chapter
Title:A New View of Innate Immunity for the 21st Century
ISBN:1405122196
ISBN-13:9781405122191
Keywords:Medical
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute

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