Stephanou, A and Knight, RA and Annicchiarico-Petruzzelli, M and Finazzi-Agrò, A and Lightmann, SL and Melino, G (1992) Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively. Funct Neurol , 7 (2) 129 - 133.
Abstract
We report the expression of different interleukins (IL) in four human glioblastoma and neuroblastoma cell lines. The glioblastoma cell line LI, expresses IL-1 beta and IL-6 mRNA, though not IL-2 and IL-4. The expression of the former gene is modulated by retinoic acid. Two cell clones [BE(2)-C and BE(2)-M17] as well as the neuroblastoma cell line SK-N-BE(2), from which both clones were derived, express IL-6 mRNA, but not IL-1 beta, IL-2 or IL-4. Both IL-1 beta and IL-6 cytokines are known to increase hypothalamic CRH mRNA, a gene reported to be expressed in all these cell lines. The production of both cytokines and neuropeptides indicates a complex dialogue between tumour cells and anti-tumour immunity.
| Type: | Article |
|---|---|
| Title: | Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively. |
| Location: | ITALY |
| Open access status: | An open access publication |
| Publisher version: | http://www.functionalneurology.it/ |
| Language: | English |
| Keywords: | Blotting, Northern, Brain Neoplasms, Cell Line, Female, Glioma, Humans, Interleukin-1, Interleukin-6, Male, Neuroblastoma, RNA, Messenger, Tumor Cells, Cultured |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Genes, Development and Disease > ICH - Medical Molecular Biology Unit |
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