Stephanou, A and Knight, RA and Annicchiarico-Petruzzelli, M and Finazzi-Agrò, A and Lightmann, SL and Melino, G (1992) Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively. Funct Neurol , 7 (2) 129 - 133.
We report the expression of different interleukins (IL) in four human glioblastoma and neuroblastoma cell lines. The glioblastoma cell line LI, expresses IL-1 beta and IL-6 mRNA, though not IL-2 and IL-4. The expression of the former gene is modulated by retinoic acid. Two cell clones [BE(2)-C and BE(2)-M17] as well as the neuroblastoma cell line SK-N-BE(2), from which both clones were derived, express IL-6 mRNA, but not IL-1 beta, IL-2 or IL-4. Both IL-1 beta and IL-6 cytokines are known to increase hypothalamic CRH mRNA, a gene reported to be expressed in all these cell lines. The production of both cytokines and neuropeptides indicates a complex dialogue between tumour cells and anti-tumour immunity.
|Title:||Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively.|
|Open access status:||An open access publication|
|Keywords:||Blotting, Northern, Brain Neoplasms, Cell Line, Female, Glioma, Humans, Interleukin-1, Interleukin-6, Male, Neuroblastoma, RNA, Messenger, Tumor Cells, Cultured|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Genes, Development and Disease > ICH - Medical Molecular Biology Unit|
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