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Phosphatidylinositol 4-kinase type II-alpha

Hsuan, JJ; Minogue, S; Waugh, MG; (2008) Phosphatidylinositol 4-kinase type II-alpha. [Digital scholarly resource]. http://www.signaling-gateway.org/molecule/query?afcsid=A002426&mpv=1

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Abstract

The phosphatidylinositol 4-kinase (PI4K) class of enzyme activities is ubiquitous in eukaryotic cells and catalyses the phosphorylation of the membrane lipid phosphatidylinositol at the 4-OH position of the inositol residue, thereby generating phosphatidylinositol 4-monophosphate (PI(4)P). PI(4)P has important roles in signaling and intracellular membrane trafficking, most notably as a signaling precursor in phosphoinositide 3-kinase (PI3K) and phospholipase C pathways. However, it is also known that PI(4)P signals by recruiting cognate PH-domain-containing proteins involved in intracellular traffic, and the clathrin adaptors AP-1 and AP-3 to their target membranes. Such PI(4)P-protein interaction phenomena have only been described relatively recently and it is likely that many more direct targets of PI(4)P exist. The α and β isoforms (PI4KIIα and PI4KIIβ) that make up the type II PI4K family are structurally and biochemically distinct from type III PI4K enzymes, which are members of the PI3K family.

Type:Digital scholarly resource
Title:Phosphatidylinositol 4-kinase type II-alpha
DOI:10.1038/mp.a002426.01
Publisher version:http://www.signaling-gateway.org/molecule/query?afcsid=A002426&mpv=1
Language:English

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