UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Late diabetes complications and non-dipping phenomenon in patients with type 1 diabetes

Stella, P; Tabak, AG; Zgibor, JC; Orchard, TJ; (2006) Late diabetes complications and non-dipping phenomenon in patients with type 1 diabetes. DIABETES RES CLIN PR , 71 (1) 14 - 20. 10.1016/j.diabres.2005.05.001.

Full text not available from this repository.

Abstract

Background: Cardiovascular autonomic neuropathy (CAN) has been thought to underlie the loss of normal nocturnal blood pressure dipping, which is associated with a higher risk for nephropathy in Type I diabetes. Previous analyses also suggest however that nephropathy is a major predictor of subsequent CAN.Objective: To investigate links between non-dipping phenomenon (NDP) and complications, particularly CAN and nephropathy.Methods: 24-h ambulatory blood pressure monitoring was performed on 61 consecutively recruited subjects (mean age: 38.5 +/- 8.1, mean duration: 29.5 +/- 8.2 years) from the Pittsburgh Epidemiology of Diabetes Complications cohort (658 subjects with chiLdhood onset Type I diabetes diagnosed between 1950 and 80). NDP was diagnosed if nocturnal fall of both systolic and diastolic blood pressure was < 10% of the average daytime blood pressure. CAN was detected by abnormal (<= 1.1) expiration/inspiration heart rate ratio. Proteinuria was established by abnormal (> 20 mu g/min) albumin excretion rate (AER) in at least two of three timed urines.Results: Non-dippers (n = 17) had greater LDLc (p = 0.012) and AER (p = 0.052) and a higher frequency of nephropathy (OR = 3.6, 95% CI = 1.0-12.6) and proliferative retinopathy (OR = 5.1, 95% CI = 1.3-20.3) compared to the 44 dippers. CAN and NDP were not associated. In multivariate analyses, adjusting for CAN, proteinuria was significantly related to NDP (OR = 3.6, 95% CI = 1.0-12.6), an association that further modeling suggests was related to interactions between nephropathy, LDLc and hypertension.Conclusions: These data suggest a strong link between NDP and proteinuria which is independent of CAN and may be modified by LDLc and hypertension. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Late diabetes complications and non-dipping phenomenon in patients with type 1 diabetes
DOI: 10.1016/j.diabres.2005.05.001
Keywords: late diabetes complications, non-dipping phenomenon, type 1 diabetes, AMBULATORY BLOOD-PRESSURE, DENSITY-LIPOPROTEIN CHOLESTEROL, CARDIAC AUTONOMIC NEUROPATHY, PITTSBURGH EPIDEMIOLOGY, IDDM PATIENTS, RISK-FACTORS, HYPERTENSION, MELLITUS, MICROALBUMINURIA, NEPHROPATHY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/61653
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item