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Myocardial infarction is associated with Sp1 binding site polymorphism of collagen type 1A1 gene

Speer, G; Szenthe, P; Kosa, JP; Tabak, AG; Folhoffer, A; Fuszek, P; Cseh, K; (2006) Myocardial infarction is associated with Sp1 binding site polymorphism of collagen type 1A1 gene. ACTA CARDIOL , 61 (3) 321 - 325.

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Abstract

Objective - Human atherosclerotic lesions contain collagen type 1, which plays a pivotal role in atherosclerotic plaque stability. In contrast, the normal coronary arteries do not express this type of collagen. Data have shown that the collagen type IAI (COLIAI) gene SpI binding site (-1245 G/T) polymorphism is associated with disturbed collagen protein production.Methods - In our study, COLIAI gene SpI polymorphism was investigated in 136 patients with myocardial infarction (MI) 5 months after the acute phase, and 212 age-matched control subjects in association with any cardiovascular risk factors (such as serum adiponectin levels, hyperinsulinaemic status, hyperlipaemia).Results - The "SS" genotype of the COLIAI gene was found to occur significantly more frequently in patients surviving a MI, as compared to the control group and the "Ss" and "ss" genotype frequencies (the presence of the s allele) were lower in our patients, than in control group. However, the occurrence of cardiovascular risk factors was significantly higher among the "s" allelic carriers as compared to patients carrying the "S" allele of the COLIAI gene.Conclusion - Our results raise the possibility that COLIAI gene SpI polymorphism might have an impact on the development of MI.

Type: Article
Title: Myocardial infarction is associated with Sp1 binding site polymorphism of collagen type 1A1 gene
Keywords: collagen, risk factors, myocardial infarction, genetics, CARDIOVASCULAR-DISEASE, OSTEOPOROTIC FRACTURE, RISK, BONE, ATHEROSCLEROSIS, DENSITY, LIPIDS, LINK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/61652
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