Tedaldi, LM and Smith, MEB and Nathani, RI and Baker, JR (2009) Bromomaleimides: new reagents for the selective and reversible modification of cysteine. CHEM COMMUN (43) 6583 - 6585. 10.1039/b915136b.
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Abstract
Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.
| Type: | Article |
|---|---|
| Title: | Bromomaleimides: new reagents for the selective and reversible modification of cysteine |
| DOI: | 10.1039/b915136b |
| Keywords: | DEHYDROALANINE-CONTAINING PEPTIDES, SULFHYDRYL GROUPS, N-ETHYLMALEIMIDE, REACTIVITY, PROTEINS, CONJUGATION |
| UCL classification: | UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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