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Bromomaleimides: new reagents for the selective and reversible modification of cysteine

Tedaldi, LM; Smith, MEB; Nathani, RI; Baker, JR; (2009) Bromomaleimides: new reagents for the selective and reversible modification of cysteine. CHEM COMMUN (43) 6583 - 6585. 10.1039/b915136b.

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Abstract

Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.

Type:Article
Title:Bromomaleimides: new reagents for the selective and reversible modification of cysteine
DOI:10.1039/b915136b
Keywords:DEHYDROALANINE-CONTAINING PEPTIDES, SULFHYDRYL GROUPS, N-ETHYLMALEIMIDE, REACTIVITY, PROTEINS, CONJUGATION
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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