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Use of hydroxypropylmethylcellulose 2% for removing adherent silicone oil from silicone intraocular lenses

Wong, SC; Ramkissoon, YD; Lopez, M; Page, K; Parkin, IP; Sullivan, PM; (2009) Use of hydroxypropylmethylcellulose 2% for removing adherent silicone oil from silicone intraocular lenses. BRIT J OPHTHALMOL , 93 (8) 1085 - 1088. 10.1136/bjo.2008.153007.

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Abstract

Background/aims: To investigate the effect of hydroxypropylmethylcellulose (HPMC) on the physical interaction (contact angle) between silicone oil and a silicone intraocular lens (IOL).Methods: In vitro experiments were performed, to determine the effect of HPMC (0.5%, 1% or 2%), with or without an additional simple mechanical manoeuvre, on the contact angle of silicone oil at the surface of both silicone and acrylic (control) IOLs. A balanced salt solution chamber was used. The study group comprised 21 silicone and nine acrylic IOLs.Results: The median contact angle of silicone oil on silicone IOL was 99 degrees. The addition of HPMC 2% alone did not significantly alter the contact angle. HPMC 2% combined with an additional single mechanical manoeuvre increased the contact angle to 180 degrees (greater non-wetting), with complete separation of silicone oil from silicone IOL within 1 min. The manoeuvre alone, or in conjunction with a lower concentration of HPMC (0.5 or 1%), was ineffective in increasing the contact angle.Conclusion: We present a novel, non-toxic technique of using hydroxypropylmethylcellulose 2% combined with a simple mechanical manoeuvre, for the removal of adherent silicone oil droplets from silicone intraocular lenses.

Type:Article
Title:Use of hydroxypropylmethylcellulose 2% for removing adherent silicone oil from silicone intraocular lenses
DOI:10.1136/bjo.2008.153007
Keywords:POSTERIOR SURFACE, PROLIFERATIVE VITREORETINOPATHY, CONDENSATION, ADHESION, BIOMATERIALS, MANAGEMENT, TOLERANCE, SOLVENT
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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