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AN INTRACELLULAR STUDY OF THE EFFECTS OF GABA ON FROG TECTAL NEURONS INVITRO

SIVILOTTI, L; NISTRI, A; (1992) AN INTRACELLULAR STUDY OF THE EFFECTS OF GABA ON FROG TECTAL NEURONS INVITRO. NEUROSCI LETT , 145 (1) 28 - 32.

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Abstract

The effects of gamma-aminobutyric acid (GABA) on neurones of the amphibian optic tectum were studied with current- and voltage-clamp recording from an isolated preparation of the midbrain of the frog Rana temporaria. Bath-applied GA.BA (1 mM) enhanced depolarizing synaptic potentials evoked in layer 6 tectal neurones by orthodromic stimulation of the optic tract. GABA also facilitated Na+- and Ca2+-dependent action potentials elicited by intracellular injection of depolarizing current. These actions of GABA were associated with comparatively small changes in membrane potential and their reversal potential was dependent on the Cl- equilibrium potential. Changes in input resistance observed during application of GABA were small and in part accountable for by the rectifying properties of the cell membrane. Tetrodotoxin (TTX; 1 muM) did not block the action of GABA on these neurones. These results show that externally applied GABA was able to raise directly the intrinsic excitability of frog tectal neurones and to enhance excitatory synaptic transmission elicited by stimulation of optic nerve fibres.

Type: Article
Title: AN INTRACELLULAR STUDY OF THE EFFECTS OF GABA ON FROG TECTAL NEURONS INVITRO
Keywords: GAMMA-AMINOBUTYRIC ACID, OPTIC TECTUM, VISUAL SYSTEM, SYNAPTIC FACILITATION, GABAC RECEPTOR, EPSP, GAMMA-AMINOBUTYRIC-ACID, CENTRAL-NERVOUS-SYSTEM, OPTIC-TECTUM, SYNAPTIC TRANSMISSION, PHARMACOLOGY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/57233
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