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Tonic GABA(A) receptor-mediated signaling

Kullmann, DM; Walker, MC; (2010) Tonic GABA(A) receptor-mediated signaling. EPILEPSIA , 51 14 - 14. 10.1111/j.1528-1167.2010.02800.x.

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Abstract

P>gamma-Aminobutyric acid (GABA) mediates both fast synaptic inhibition and a tonic form of signaling that depends on high-affinity, extrasynaptic GABA(A) receptors. Tonic inhibition may contribute to the generation of spike-wave discharges. Because they have a profound effect on circuit excitability, tonically active GABA(A) receptors represent an important therapeutic target. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).

Type: Article
Title: Tonic GABA(A) receptor-mediated signaling
DOI: 10.1111/j.1528-1167.2010.02800.x
Keywords: Delta (delta) and alpha5 (alpha(5)) subunits, Epilepsy, Neurosteroids, Seizures, Thalamocortical neurons, Antiepileptic drugs, INHIBITION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: http://discovery.ucl.ac.uk/id/eprint/570240
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