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Differing actions of the acute administration of propranolol and isosorbide-5-mononitrate on the portal circulation

Forrest, EH; Jalan, R; Redhead, DN; Hayes, PC; (1996) Differing actions of the acute administration of propranolol and isosorbide-5-mononitrate on the portal circulation. ALIMENT PHARM THERAP , 10 (5) 795 - 800.

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Abstract

Background: The aim of this study was to clarify the actions of propranolol and isosorbide-5-mononitrate upon the portal circulation,Methods: Portal haemodynamics were assessed in 16 patients with transjugular intrahepatic portosystemic stent shunts. A reverse thermodilution catheter was positioned in the portal vein, and portal vein pressure and portal vein now were measured directly. The effects of propranolol 80 mg and isosorbide-5-mononitrate 20 mg over 1 h were determined independently.Results: This demonstrated that propranolol reduced both portal pressure gradient (7.7 +/- 2.3 to 5.5 +/- 2.1 mmHg, P < 0.01) and portal vein now (925 +/- 123 to 597 +/- 99 ml/min, P = 0.01) significantly, implying a reduction in splanchnic inflow as its main effect, In contrast, isosorbide-5-mononitrate tended to increase portal vein now (814 +/- 186 to 911 +/- 211 ml/min; P = 0.06) whilst reducing portal pressure significantly (108 +/- 12 to 92 +/- 10 mmHg P = 0.014), This suggests a fall in intrahepatic resistance and provides no evidence for baroreceptor-mediated reflex splanchnic vasoconstriction,Conclusions: These drugs act upon different variables contributing to portal hypertension and so they may have a powerful synergistic effect in combination, Direct measurement of portal vein now is a valuable method for assessing the pharmacological modulation of portal venous inflow.

Type:Article
Title:Differing actions of the acute administration of propranolol and isosorbide-5-mononitrate on the portal circulation
Keywords:BLOOD-FLOW, LIVER-FUNCTION, CIRRHOSIS, HYPERTENSION, HEMODYNAMICS, REDUCTION

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