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Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern.

Schaefer, AT; Larkum, ME; Sakmann, B; Roth, A; (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. J Neurophysiol , 89 (6) 3143 - 3154. 10.1152/jn.00046.2003.

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Abstract

Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative reduction in threshold for initiation of a dendritic calcium AP due to a coincident back-propagating AP. Simulations based on reconstructions of biocytin-filled cells showed that addition of oblique branches of the main apical dendrite in close proximity to the soma (d < 140 microm) increases the coupling between the apical and axosomatic AP initiation zones, whereas incorporation of distal branches decreases coupling. Experimental studies on L5 pyramids in acute brain slices revealed a highly significant (n = 28, r = 0.63, P < 0.0005) correlation: increasing the fraction of proximal oblique dendrites (d < 140 microm), e.g., from 30 to 60% resulted on average in an increase of the coupling from approximately 35% to almost 60%. We conclude that variation in dendritic arborization may be a key determinant of variability in coupling (49 +/- 17%; range 19-83%; n = 37) and is likely to outweigh the contribution made by variations in active membrane properties. Thus coincidence detection of inputs arriving from different cortical layers is strongly regulated by differences in dendritic arborization.

Type: Article
Title: Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern.
Location: United States
DOI: 10.1152/jn.00046.2003
Language: English
Keywords: Action Potentials, Animals, Dendrites, Electrophysiology, Membrane Potentials, Models, Biological, Pyramidal Cells, Rats, Rats, Wistar, Somatosensory Cortex
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/55852
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