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Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases.

Shankar, A; Loizidou, M; Burnstock, G; Taylor, I; (1999) Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases. Br J Surg , 86 (4) 453 - 457. 10.1046/j.1365-2168.1999.01045.x.

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Abstract

Vasopressors administered via the hepatic artery appear to increase drug delivery to colorectal liver metastases, but are limited by a short duration of action. This study measured their effect on blood flow and drug delivery during a prolonged infusion in a model of liver metastases.

Type:Article
Title:Noradrenaline improves the tumour to normal blood flow ratio and drug delivery in a model of liver metastases.
Location:ENGLAND
DOI:10.1046/j.1365-2168.1999.01045.x
Language:English
Keywords:Animals, Antimetabolites, Antineoplastic, Blood Flow Velocity, Chemotherapy, Cancer, Regional Perfusion, Enzyme Inhibitors, Fluorouracil, Laser-Doppler Flowmetry, Liver Neoplasms, Male, NG-Nitroarginine Methyl Ester, Norepinephrine, Rats
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School

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