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Pros and cons of L-arginine supplementation in disease

Vissers, YLJ; Debats, IBJG; Luiking, YC; Jalan, R; van der Hulst, RRWJ; Dejong, CHC; Deutz, NEP; (2004) Pros and cons of L-arginine supplementation in disease. NUTR RES REV , 17 (2) 193 - 210. 10.1079/NRR200490.

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Abstract

The amino acid arginine and one of its metabolites NO have gathered broad attention in the last decade. Although arginine is regarded as a conditionally essential amino acid in disease, L-arginine supplementation in severe illness has not found its way into clinical practice. This might be due to the invalid interpretation of results from studies with immune-enhancing diets containing L-arginine amongst other pharmaconutrients. However, not much attention is given to research using L-arginine as a monotherapy and the possibility of the alternative hypothesis: that L-arginine supplementation is beneficial in disease. The present review will discuss data from studies in healthy and diseased animals and patients with monotherapy of L-arginine to come to an objective overview of positive and negative aspects of L-arginine supplementation in disease with special emphasis on sepsis, cancer, liver failure and wound healing.

Type:Article
Title:Pros and cons of L-arginine supplementation in disease
DOI:10.1079/NRR200490
Keywords:L-arginine supplementation, nitric oxide, sepsis, cancer, wound healing, liver failure, NITRIC-OXIDE SYNTHASE, TOTAL PARENTERAL-NUTRITION, CRITICALLY-ILL PATIENTS, HUMAN SEPTIC SHOCK, ASYMMETRICAL DIMETHYLARGININE ADMA, ORTHOTOPIC LIVER-TRANSPLANTATION, PLASMA CITRULLINE CONCENTRATION, MUSCLE PROTEIN-SYNTHESIS, AMINO-ACID-METABOLISM, RAT SMALL-INTESTINE

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