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Do helminths cause epilepsy?

Wagner, RG; Newton, CR; (2009) Do helminths cause epilepsy? PARASITE IMMUNOL , 31 (11) 697 - 705. 10.1111/j.1365-3024.2009.01128.x.

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Abstract

P>Both helminthiases and epilepsy occur globally, and are particularly prevalent in developing regions of the world. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. We review the available literature on the global burden of helminths, and the epidemiological evidence linking helminths to epilepsy. We discuss possible routes that helminths affect the central nervous system (CNS) of humans and the immunological response to helminth infection in the CNS, looking at possible mechanisms of epileptogenesis. Finally, we discuss the current gaps in knowledge about the interaction between helminths and epilepsy.

Type:Article
Title:Do helminths cause epilepsy?
DOI:10.1111/j.1365-3024.2009.01128.x
Keywords:burden, epilepsy, helminths, pathogenesis, seizures, CEREBRAL SCHISTOSOMIASIS, ANTINUCLEAR ANTIBODIES, MURINE CYSTICERCOSIS, TOXOCARA INFECTION, RETARDED GROWTH, NEUROCYSTICERCOSIS, ONCHOCERCIASIS, SEIZURES, CHILDREN, INTERLEUKIN-5
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health

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