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Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole

Fisk, M; Sage, EK; Edwards, SG; Cartledge, JD; Miller, RF; (2009) Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole. INT J STD AIDS , 20 (9) 652 - 653. 10.1258/ijsa.2009.008470.

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Abstract

A retrospective case-notes audit of 359 HIV-1-infected adult patients with first-episode laboratory-confirmed Pneumocystis jirovecii pneumonia treated with co-trimoxazole (from 1987 adjuvant steroids were used if PaO2 <9.3 kPa) showed that only 230/359 (64%) patients completed treatment; 104 (29%) patients had treatment-limiting toxicity; rash occurred in 4/60 (6.7%) patients in 1985-1988 and in 15/47 (31.9%) in 2005-2008. Twenty-five patients (7%) failed co-trimoxazole treatment. Overall mortality was 13.6% (49/359); mortality among patients who failed co-trimoxazole treatment was 48% (12/25) and by contrast mortality was 4.8% (5/104) among patients with treatment-limiting toxicity.

Type: Article
Title: Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole
DOI: 10.1258/ijsa.2009.008470
Keywords: co-trimoxazole, Pneumocystis jirovecii, toxicity, treatment failure, ACQUIRED-IMMUNODEFICIENCY-SYNDROME, TRIMETHOPRIM-SULFAMETHOXAZOLE, CARINII PNEUMONIA, PENTAMIDINE, TRIAL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/54768
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