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High resolution Ca/P maps of bone architecture

Tzaphlidou, M; Speller, R; Royle, G; Griffiths, J; (2004) High resolution Ca/P maps of bone architecture. IEEE Nuclear Science Symposium Conference Record , 5 pp. 3267-3270.

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The Ca/P ratio was measured in cortical bone samples from the femoral neck, front and rear tibia of female rats (1.5 yr of age), using synchrotron radiation microtomography. Use of a monoenergetic x-ray beam, as provided by the synchrotron facility, generates accurate 3-D maps of the linear attenuation coefficient within the sample and hence gives the ability to map different chemical components. MicroCT data sets were collected at 20 and 28 keV for each bone sample and two calibration phantoms. From the 3-D data sets, multiple 2-D slices were reconstructed with a slice thickness of ∼14 μm. Regions of interest were defined around suitable sites and were converted to Ca/P ratios using the data collected from the test phantoms. Mean values (M+SD) for cortical femoral, front and rear tibias are: 2.12+0.08, 1.75+0.06 and 1.94+0.07 respectively. Differences between the same bone sites from different animals are not significant (0.3 < p < 0.5) while those between different bone sites are highly significant (p < 10 -3 ). Differences between estimates made at 20 and 28 keV are not significant (p > 0.5). © 2004 IEEE.

Type: Article
Title: High resolution Ca/P maps of bone architecture
UCL classification: UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
UCL > VP Education
URI: http://discovery.ucl.ac.uk/id/eprint/546730
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