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Cell cycle switch to endocycle - The nucleolus lends a hand

Martindill, DMJ; Riley, PR; (2008) Cell cycle switch to endocycle - The nucleolus lends a hand. CELL CYCLE , 7 (1) 17 - 23.

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Abstract

The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis but how its developmental activity is regulated is largely unknown. We recently showed that Hand1 is sequestered in the nucleoli of rodent trophoblast stem (TS) cells by the I-mfa domain-containing protein HICp40 and that this is associated with their proliferation and continuing self-renewal. However when these cells commit to differentiate into trophoblast giant (TG) cells, Hand1 is phosphorylated by the polo-like kinase Plk4 (Sak) and released into the nucleus to activate downstream target genes. This event underlies the release of Hand1 from the nucleolus and represents the 'molecular switch' that promotes mitotic cell cycle exit and the onset of endoreduplication. In this brief discussion we examine the wider implications of these findings and address some of the unanswered questions that remain.

Type: Article
Title: Cell cycle switch to endocycle - The nucleolus lends a hand
Keywords: hand1, nucleolus, trophoblast, endoreduplication, Plk4, HICp40, TROPHOBLAST GIANT-CELLS, POLO-LIKE KINASE, HELIX TRANSCRIPTION FACTORS, ANAPHASE-PROMOTING COMPLEX, DROSOPHILA FOLLICLE CELLS, UBIQUITIN LIGASE ACTIVITY, HUMAN CDC14A PHOSPHATASE, MFA DOMAIN PROTEINS, STEM-CELLS, PLACENTAL DEVELOPMENT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/54637
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