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Isolation of silver- and antibiotic-resistant Enterobacter cloacae from teeth

Davis, IJ; Richards, H; Mullany, P; (2005) Isolation of silver- and antibiotic-resistant Enterobacter cloacae from teeth. ORAL MICROBIOL IMMUN , 20 (3) 191 - 194.

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Abstract

Antibiotic-resistant bacteria pose a serious threat to human health; hence the mechanisms that lead to their selection need to be investigated. One possible mechanism is that the silver and mercury in amalgam dental restorations may select for bacteria that contain heavy metal and antibiotic-resistance determinants, leading to the spread of these resistances, particularly if they are contained on the same mobile genetic element. The incidence of silver-resistant bacteria on teeth is investigated in this work. Two silver-resistant Enterobacter cloacae isolates were isolated from infected teeth containing dental restorations. Both isolates were also resistant to ampicillin, erythromycin, and clindamycin. The silE gene, which is encoded on the silver resistance operon, has been sequenced from both isolates. Results suggest that the silver resistance operon is encoded on plasmid DNA.

Type:Article
Title:Isolation of silver- and antibiotic-resistant Enterobacter cloacae from teeth
Keywords:antibiotic resistance, dental amalgam, Enterobacter cloacae, sil, silver resistance, MERCURY-RESISTANT, AMALGAM FILLINGS, PLASMID, SUSCEPTIBILITY, BACTERIA, SALMONELLA, PREVALENCE, AMPICILLIN, EXPOSURE, ELEMENT
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases

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