UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Adefovir dipivoxil: review of a novel acyclic nucleoside analogue

Danta, M; Dusheiko, G; (2004) Adefovir dipivoxil: review of a novel acyclic nucleoside analogue. INT J CLIN PRACT , 58 (9) 877 - 886. 10.1111/j.1368-5031.2004.00364.x.

Full text not available from this repository.

Abstract

Adefovir dipivoxil (ADF) is a novel acyclic nucleoside analogue that has recently been approved for the treatment of chronic hepatitis B virus (HBV). Adefovir was initially assessed at higher doses for the treatment of human immunodeficiency virus (HIV) infection. However, in these studies, nephrotoxicity proved a dose-limiting side effect. Large randomised controlled studies have recently shown that ADF results in histological, virological and biochemical improvement in both hepatitis B e antigen (HBeAg)positive and HBeAg-negative chronic HBV. While the rate of HBeAg seroconversion at 1 year (12%) was lower than both lamivudine and interferon, this increases with prolonged treatment. The clinical improvements occurred without serious side effects or the development of resistance at the dose of 10 mg daily, in treatment trials of up to 2 years, although resistance has now been observed. In addition, the drug is efficacious in HBV/HfV co-infection and hepatitis B-infected liver transplant recipients, particularly in those who have developed lamivudine resistance. ADF can be added as a treatment option to existing treatment options (interferon-alpha and lamivudine) and assumes a role in the ongoing management of chronic H13V. The optimal use of ADF as either a monotherapy or as part of combination therapy requires further assessment.

Type: Article
Title: Adefovir dipivoxil: review of a novel acyclic nucleoside analogue
DOI: 10.1111/j.1368-5031.2004.00364.x
Keywords: adefovir, adefovir dipivoxil, nucleoside analogue, hepatitis B, HBV, HIV, treatment, HEPATITIS-B-VIRUS, HUMAN-IMMUNODEFICIENCY-VIRUS, FIBROSING CHOLESTATIC HEPATITIS, ORGANIC ANION TRANSPORTER, MITOCHONDRIAL-DNA DEPLETION, PLACEBO-CONTROLLED TRIAL, HIV-INFECTED PATIENTS, TERM-FOLLOW-UP, LIVER-TRANSPLANTATION, IN-VITRO
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/54372
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item