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Adefovir dipivoxil: review of a novel acyclic nucleoside analogue

Danta, M; Dusheiko, G; (2004) Adefovir dipivoxil: review of a novel acyclic nucleoside analogue. INT J CLIN PRACT , 58 (9) 877 - 886. 10.1111/j.1368-5031.2004.00364.x.

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Abstract

Adefovir dipivoxil (ADF) is a novel acyclic nucleoside analogue that has recently been approved for the treatment of chronic hepatitis B virus (HBV). Adefovir was initially assessed at higher doses for the treatment of human immunodeficiency virus (HIV) infection. However, in these studies, nephrotoxicity proved a dose-limiting side effect. Large randomised controlled studies have recently shown that ADF results in histological, virological and biochemical improvement in both hepatitis B e antigen (HBeAg)positive and HBeAg-negative chronic HBV. While the rate of HBeAg seroconversion at 1 year (12%) was lower than both lamivudine and interferon, this increases with prolonged treatment. The clinical improvements occurred without serious side effects or the development of resistance at the dose of 10 mg daily, in treatment trials of up to 2 years, although resistance has now been observed. In addition, the drug is efficacious in HBV/HfV co-infection and hepatitis B-infected liver transplant recipients, particularly in those who have developed lamivudine resistance. ADF can be added as a treatment option to existing treatment options (interferon-alpha and lamivudine) and assumes a role in the ongoing management of chronic H13V. The optimal use of ADF as either a monotherapy or as part of combination therapy requires further assessment.

Type:Article
Title:Adefovir dipivoxil: review of a novel acyclic nucleoside analogue
DOI:10.1111/j.1368-5031.2004.00364.x
Keywords:adefovir, adefovir dipivoxil, nucleoside analogue, hepatitis B, HBV, HIV, treatment, HEPATITIS-B-VIRUS, HUMAN-IMMUNODEFICIENCY-VIRUS, FIBROSING CHOLESTATIC HEPATITIS, ORGANIC ANION TRANSPORTER, MITOCHONDRIAL-DNA DEPLETION, PLACEBO-CONTROLLED TRIAL, HIV-INFECTED PATIENTS, TERM-FOLLOW-UP, LIVER-TRANSPLANTATION, IN-VITRO
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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