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Noradrenaline clearance differs in the frontal cortex and hypothalamus: a dual-probe microdialysis study in freely-moving rats

Geranton, SM; Heal, DJ; Stanford, SC; (2003) Noradrenaline clearance differs in the frontal cortex and hypothalamus: a dual-probe microdialysis study in freely-moving rats. NEUROSCI LETT , 350 (3) 157 - 160. 10.1016/S0304-3940(03)00912-1.

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Abstract

The noradrenergic innervation of the frontal cortex and the hypothalamus arises from different brainstem nuclei and neurones projecting to these two brain regions differ topographically and morphologically. In the present study, we investigated whether there is a difference in noradrenaline clearance in these two brain areas using dual-probe microdialysis in freely-moving rats. Noradrenaline clearance was determined simultaneously in each brain area by measuring the noradrenaline extraction fraction using the 'No Net Flux' method, with both brain regions perfused with the same solutions. The noradrenaline extraction fraction was greater in the frontal cortex than in the hypothalamus (72 and 54%, respectively). This finding suggests that the processes involved in noradrenaline clearance, especially uptake, are more efficient in the former brain area, which could explain the differences in the increase in noradrenaline efflux when these brain areas are challenged with drugs that alter the function of the central nervous system. (C) 2003 Published by Elsevier Ireland Ltd.

Type: Article
Title: Noradrenaline clearance differs in the frontal cortex and hypothalamus: a dual-probe microdialysis study in freely-moving rats
DOI: 10.1016/S0304-3940(03)00912-1
Keywords: clearance, extraction fraction, frontal cortex, hypothalamus, microdialysis, noradrenaline, EXTRACTION FRACTION, TRANSPORTER, NOREPINEPHRINE, DOPAMINE, EXPRESSION, DSP-4
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/54253
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