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Direct and cross-protective effects of heat adaptation in cultured cells

Monastyrkaya, EA; Andreeva, LV; Duchen, MR; Manuknina, EB; Malyshev, IY; (2003) Direct and cross-protective effects of heat adaptation in cultured cells. B EXP BIOL MED+ , 135 (2) 127 - 129.

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Abstract

The model of 6-day dosed heat adaptation was developed on cultured rat H9c2 cardiomyoblasts and mouse C2c12 myoblasts. Heat adaptation produced a direct protective effect and increased the resistance of cells to heat shock. The cross-protective effect of heat adaptation was manifested in an increase in the resistance to staurosporine-induced damage. Heat adaptation did not protect cells from oxidative damage. As differentiated from adaptation of the organism, heat adaptation produces direct and cross-protective effects that develop due to the action of environmental factors in the absence of neurohumoral agents. It should be emphasized that the cross-protective effect of heat adaptation in cultured cells is specific to a certain type of damage.

Type: Article
Title: Direct and cross-protective effects of heat adaptation in cultured cells
Keywords: heat adaptation, cell culture, heat shock, staurosporine, oxidative stress, NITRIC-OXIDE, RESISTANCE, ISCHEMIA, STRESS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/54234
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