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Antiapoptotic effect of heat adaptation in cultured cells

Monastyrskaya, EA; Duchen, MR; Andreeva, LV; Viegant, F; Manukhina, EB; Malyshev, IY; (2003) Antiapoptotic effect of heat adaptation in cultured cells. B EXP BIOL MED+ , 135 (2) 123 - 126.

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Abstract

Heat adaptation of cultured rat cardiomyoblasts and mouse myoblasts protected these cells from damage produced by staurosporine and attenuated metabolic disturbances. Heat adaptation inhibited apoptotic, but not necrotic cell death. The mechanism of antiapoptotic adaptive protection was not associated with prevention of mitochondrial depolarization, because heat adaptation not only induced depolarization of mitochondria, but also intensified this process under conditions of staurosporine-induced damage.

Type: Article
Title: Antiapoptotic effect of heat adaptation in cultured cells
Keywords: heat adaptation, cell culture, apoptosis, mitochondria, CARDIOMYOCYTES, MITOCHONDRIA, APOPTOSIS, GROWTH, DEATH
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/54233
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