UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Targeted retroviral infection of tumor cells by receptor cooperation

Martin, F; Chowdhury, S; Neil, SJ; Chester, KA; Cosset, FL; Collins, MK; (2003) Targeted retroviral infection of tumor cells by receptor cooperation. J VIROL , 77 (4) 2753 - 2756. 10.1128/JVI.77.4.2753-2756.2003.

Full text not available from this repository.

Abstract

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.

Type: Article
Title: Targeted retroviral infection of tumor cells by receptor cooperation
DOI: 10.1128/JVI.77.4.2753-2756.2003
Keywords: CARCINOEMBRYONIC ANTIGEN, ENVELOPE PROTEIN, BINDING DOMAIN, MELANOMA-CELLS, GENE-THERAPY, VECTORS, ANTIBODY, FUSION, TRANSDUCTION, GENERATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: http://discovery.ucl.ac.uk/id/eprint/54179
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item