Martin, D; McCorkell, S; Vercueil, A; Gunning, P; Cox, M; Dick, J; ... Grocott, M; + view all Martin, D; McCorkell, S; Vercueil, A; Gunning, P; Cox, M; Dick, J; Mythen, M; Grocott, M; - view fewer (2007) Increased gastric-end Tidal P-CO2 gap during exercise at high altitude measured by gastric tonometry. HIGH ALT MED BIOL , 8 (1) 50 - 55. 10.1089/ham.2006.1022.
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Using automated air gastric tonometry, the hypothesis that gastric perfusion. is reduced while exercising at high altitude was explored. This prospective observational study of 5 well acclimatized healthy volunteers was performed during a medical research expedition to Chamlang base camp (5000 m), Hongu valley, Nepal. We used gastric tonometry at rest and during graded submaximal exercise. The end-tidal partial pressure of carbon dioxide was subtracted from the gastric mucosal partial pressure of carbon dioxide to calculate the P-CO2 gradient, which is a marker of gastric mucosal perfusion. When compared with rest, there was no increase in the mean P-CO2 gradient at the lower work rate (0.22 vs. 0.18, p = 0.10), but an increase was seen between rest and the higher work rate (0.22 vs. 0.77, p = 0.04). We conclude that exercising while at high altitude can lead to a raised P-CO2 gradient when gastric tonometry is performed, indicating reduced perfusion. This may represent reduced gastric mucosal perfusion under these conditions.
|Title:||Increased gastric-end Tidal P-CO2 gap during exercise at high altitude measured by gastric tonometry|
|Keywords:||gastric tonometry, exercise at high altitude, intestinal blood flow, mucosal perfusion, carbon dioxide, BLOOD-FLOW, TISSUE OXYGENATION, HEALTHY-VOLUNTEERS, CARDIAC-SURGERY, MUCOSAL, DIFFERENCE, PERFUSION, ISCHEMIA, PCO2, DOG|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Cardiorespiratory Sciences > ICH - Portex Anaesthesia
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