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Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes

Railson, J; Lawrence, K; Stephanou, A; Brar, B; Pennica, D; Latchman, D; (2000) Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes. CYTOKINE , 12 (11) 1741 - 1744.

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Abstract

Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting that it occurs at the post-transcriptional level. Pre-treatment with CT-1 reduces the ability of heat shock to induce hsp expression and this effect occurs at the transcriptional level. Hence, CT-1 and stress induce the hsps via different pathways which can antagonise one another. The mechanisms of these effects and their potential impact on the use of CT-1 as a cardioprotective agent are discussed. (C) 2000 Academic Press.

Type: Article
Title: Cardiotrophin-1 reduces stress-induced heat shock protein production in cardiac myocytes
Keywords: cardiotrophin-1, heat shock protein, hsp70, hsp90, post-transcriptional, antagonism, cardiocyte, heart, HYPERTROPHY, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Genetics and Genomic Medicine Prog
URI: http://discovery.ucl.ac.uk/id/eprint/53925
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