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Quantitative imaging in time-resolved transillumination experiments using time-dependent contrast functions

Chernomordik, V; Hattery, D; Gandjbakhche, AH; Pifferi, A; Taroni, P; Torricelli, A; Valentini, G; ... Hebden, JC; + view all (1999) Quantitative imaging in time-resolved transillumination experiments using time-dependent contrast functions. In: Chance, B and Alfano, RR and Tromberg, BJ and Katzir, A, (eds.) OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF. (pp. 398 - 402). SPIE-INT SOC OPTICAL ENGINEERING

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Abstract

We have developed a random walk model that uses time-dependent contrast functions to quantify the cross-section and the diffusion and absorption coefficients of an optically abnormal target from time-of-flight (TOE) data obtained in time-resolved transillumination experiments'. To substantiate our methodology we have used two different sets of data. The first set of data, provided by colleagues at University College London, are TOF measurements obtained using a solid phantom whose thickness (55mm), optical properties (absorption, mu(a)=0.006mm(-1), transport corrected scattering, mu(sc)'=0.7mm(-1)), and characteristics of its abnormal target (size=5mm, optical properties twice those of the background) are close to those of a human breast. The second set of data, provided by colleagues at Politecnico di Milan, are TOF measurements on a 50mm thick phantom (mu(a)=0.01mm(-1), mu(sc)'=1mm(-1)) in which two 10mm abnormal targets (one abnormally scattering, mu(sc)'=2mm(-1); one abnormally absorbing and scattering, mu(a)=0.04mm(-1), mu(sc)'=2mm(-1)), are embedded. None of these data includes very short path photons whose measurements are clinically impractical. Using our time-dependent contrast functions, we were able to estimate the size and optical properties of the targets with an error margin of 3-25%.

Type: Proceedings paper
Title: Quantitative imaging in time-resolved transillumination experiments using time-dependent contrast functions
Event: Conference on Optical Tomography and Spectroscopy of Tissue III
Location: SAN JOSE, CA
Dates: 1999-01-24 - 1999-01-28
ISBN: 0-8194-3067-6
Keywords: time-resolved transillumination, quantitative imaging, random walk, contrast functions, breast screening, MEDICINE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/53781
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