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Sex specific X chromosome expression caused by genomic imprinting

Iwasa, Y; Pomiankowski, A; (1999) Sex specific X chromosome expression caused by genomic imprinting. J THEOR BIOL , 197 (4) 487 - 495.

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Abstract

The conflict theory of genomic imprinting predicts that imprinted genes are growth enhancing when paternally expressed and growth suppressing when maternally expressed. The expression pattern of autosomal imprinted genes generally fits these predictions. However, the conflict theory cannot easily account for the pattern of X-linked imprinting in humans and mice. This has led us to propose a novel hypothesis that X-linked imprinting has evolved to control sex specific gene expression in early embryos. The hypothesis links paternal X-imprinting (i.e. paternal copy silencing) to random X-inactivation and the retention of Y-linked copies, and links maternal X-imprinting to escape from random X-inactivation and the loss of Y-linked copies. The hypothesis offers a good explanation of the existing data on X-imprinted genes. (C) 1999 Academic Press.

Type: Article
Title: Sex specific X chromosome expression caused by genomic imprinting
Keywords: MAMMALIAN Y-CHROMOSOME, EMBRYONIC GROWTH, CONFLICT THEORY, EVOLUTION, MOUSE, INACTIVATION, DIFFERENTIATION, ESCAPE, GENES, SRY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/53734
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