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Cerebral blood flow increases over the first three days of life in extremely preterm neonates

Meek, FH; Tyszczuk, L; Elwell, CE; Wyatt, JS; (1998) Cerebral blood flow increases over the first three days of life in extremely preterm neonates. ARCH DIS CHILD , 78 (1) F33 - F37.

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Abstract

Aim-To measure changes in cerebral haemodynamics over the first three days of life in very preterm infants with normal brains.Methods-Eleven mechanically ventilated infants (median gestational age 26 weeks) without evidence of major abnormalities on cranial ultrasound examination were studied. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using near infrared spectroscopy at least twice over the first three days of life.Results-Cerebral blood flow increased significantly with time (p=0.02; stepwise linear regression) and this was independent of mean arterial blood pressure, PaCO2, and haematocrit.Conclusion-This change is likely to represent a normal adaptive response of the cerebral circulation to postnatal life.

Type: Article
Title: Cerebral blood flow increases over the first three days of life in extremely preterm neonates
Keywords: cerebral blood flow, cerebral haemodynamics, near infrared spectroscopy, extremely preterm, NEAR-INFRARED SPECTROSCOPY, LEFT-VENTRICULAR OUTPUT, NEWBORN-INFANTS, POSTNATAL CHANGES, XE-133 CLEARANCE, FULL-TERM
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/53561
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