UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Parental growth at different life stages and offspring birthweight: an intergenerational cohort study

Hypponen, E; Power, C; Smith, GD; (2004) Parental growth at different life stages and offspring birthweight: an intergenerational cohort study. PAEDIATR PERINAT EP , 18 (3) 168 - 177.

Full text not available from this repository.

Abstract

Using three generations of the 1958 British national birth cohort we investigated ways in which parental size is related to offspring birthweight. By age 41 years, 4566 singleton female and 4050 male cohort members (born 3-9 March, 1958) had become parents and provided information on their singleton offspring.Mother's birthweight (standardised for gestational age and sex) was the strongest determinant of offspring birthweight (effect size [ES] per SDS 112 g [95% CI 97, 128]), which was little affected by adjustment for maternal height or BMI (ES 95 g and 105 g respectively). The intergenerational birthweight association was not observed for mothers born very small or large. Mother's childhood height at age 7 (ES 46 g [24, 67]), but not BMI (ES 3 g [-18, 23]), was associated with offspring birthweight after adjustment for grandparental size, own birthweight, and adult size. Controlling for other growth measures strongly attenuated the association between mother's adult height and offspring birthweight: (ES 90 g, unadjusted, and 25 g, adjusted), while the association between adult BMI and offspring birthweight was little affected (ES 55 g and 51 g respectively). Father's BMI did not affect offspring birthweight, while the associations for height were similar, albeit weaker, than those observed for the mother. Our results suggest that intergenerational associations in birthweights are largely independent of postnatal size. Maternal height in childhood was positively related to offspring birthweight, while the effect of her BMI was restricted to adulthood.

Type: Article
Title: Parental growth at different life stages and offspring birthweight: an intergenerational cohort study
Keywords: LINEAR GROWTH, CHILDREN, PREGNANCY, ORIGINS, OBESITY, RATES, WELL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/53355
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item