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Heteromeric assembly of Kv2.1 with Kv9.3: Effect on the state dependence of inactivation

Kerschensteiner, D; Stocker, M; (1999) Heteromeric assembly of Kv2.1 with Kv9.3: Effect on the state dependence of inactivation. BIOPHYS J , 77 (1) 248 - 257.

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Abstract

Modulatory ar-subunits of Ky channels remain electrically silent after homomeric expression. Their interactions with Kv2 alpha-subunits via the amino-terminal domain promote the assembly of heteromeric functional channels. The kinetic features of these heteromers differ from those of Kv2 homomers, suggesting a distinct role in electrical signaling. This study investigates biophysical properties of channels emerging from the coexpression of Kv2.1 with the modulatory alpha-subunit Kv9.3. Changes relative to homomeric Kv2.1 concern activation, deactivation, inactivation, and recovery from inactivation. A detailed description of Kv2.1/Kv9.3 inactivation is presented. Kv2.1/Kv9.3 heteromers inactivate in a fast and complete fashion from intermediate closed states, but. in a slow and incomplete manner from open states. Intermediate closed states of channel gating can be approached through partial activation or deactivation, according to a proposed qualitative model. These transitions are rate-limiting for Kv2.1/Kv9.3 inactivation. Finally, based on the kinetic description, we propose a putative function for Kv2.1/Kv9.3 heteromers in rat heart.

Type: Article
Title: Heteromeric assembly of Kv2.1 with Kv9.3: Effect on the state dependence of inactivation
Keywords: RAT VENTRICULAR MYOCYTES, CHANNEL ALPHA-SUBUNITS, C-TYPE INACTIVATION, K+ CHANNEL, POTASSIUM-CHANNEL, DELAYED-RECTIFIER, XENOPUS-OOCYTES, BRAIN, EXPRESSION, SHAB
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/52917
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