Fundamentals of Pharmaceutical Nanoscience.
© Springer Science+Business Media New York 2013. And Gregor Cevc 2013. All rights reserved. Nanoscience is the study of properties and characteristics that are unique to the nanoscale and pharmaceutical nanoscience is the application of the ensuing knowledge to the development of pharmaceuticals. Materials properties residing at the nanoscale have been found to offer a number of pharmaceutical products advanced functionality. Nanoparticles are fabricated from various chemistries, e.g. polymer-drug conjugates, self-assembled polymers, self-assembled low molecular weight amphiphiles, silica, crystalline iron salts, hydrophobic polymer nanoprecipitates and drug nanocrystals. Principally, with nano-enabled entities, there is unprecedented control of the in vivo fate of the drug compound and the science has subsequently already led to a number of approved products, e.g. Doxil, Ambisome and Abraxane with others in clinical development. As well as being able to control the biodistribution of drug compounds, emerging applications of pharmaceutical nanoscience include the use of nanofabricated materials for regenerative medicine and their application in diagnostic imaging.
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